Hereditary angioedema (HAE) is a rare genetic disease. It is known to be diagnosed in about 1 in 10,000 to 50,000 people globally. The condition affects the immune system’s ability to manage inflammation in the body. This results in several symptoms that affect the skin, airway, and gastrointestinal system. Most of these symptoms are similar to allergic reactions. Therefore, it is important to recognize the early signs of HAE to enable timely diagnosis and treatment. Early signs Before the onset of the symptoms, one can experience several of these early signs of HAE: Extreme fatigue Painless and non-itchy rash Muscle ache Skin tightness Tingling skin Headache Anxiety Abdomen pain Hoarseness of voice Mood changes or irritability Common symptoms The early signs are often followed by an HAE attack. During this, a person experiences swelling in different areas of the body. This leads to the start of the following symptoms: Swelling of the skin This is one of the most common symptoms of HAE. Its early signs are tingling and tightness of skin, which progress to painful and extreme swelling of the skin. If not treated on time, the swelling may subside in a couple of days. It is always recommended to seek medical care to avoid other severe symptoms from occurring.